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CYTUVA

University Institute of Applied Ophthalmobiology (IOBA)

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Contact Information

Basic Information

  • UniversityUniversidad de Valladolid
  • CenterInstitute of Applied Ophthalmobiology (IOBA)
  • Department-
  • Investigation GroupInstitute of Applied Ophthalmobiology (IOBA)


Description

The University Institute of Applied Ophthalmobiology of the University of Valladolid (IOBA) is a pioneering center, which was born within the University of Valladolid 25 years ago, with a triple aspect:
  • Clinic
  • Researcher
  • Trainer
The IOBA competes in quality and results with the best European centers. Its researchers and clinicians combine their healthcare work with research projects and teaching activities.

The IOBA is the first LRU Institute (University Reform Law) of the University of Valladolid, the first in Castilla y León and the first in Spain dedicated to Ophthalmology and Vision Sciences.

Its main objective is to respond to the need to deepen the knowledge of the biological bases, of the diagnostic and therapeutic methods related to eye diseases, as well as the practical application of such knowledge to the prevention, diagnosis, treatment, and rehabilitation of the same.

Located on the Miguel Delibes campus, it has more than 3,500 square meters distributed over three floors and a basement.The four floors are dedicated to each of the facets of the Institute's activity:
  • The basement has three operating rooms, a resuscitation room, recovery boxes and the controlled environment laboratory.
  • The ground floor is for clinical patient care, with 14 medical cabinets and multiple complementary examination and testing rooms.
  • The first floor is for the research and diagnosis area, with 7 laboratories: eye pathology, molecular biology, cell cultures, retina, eye surface, and cell therapy and a common laboratory.
  • The second and last floor is for the training and administration area with meeting rooms, classrooms and a library.
Research results and their application:

The main results and their derived application, arising from the IOBA's research activities, include:
  • Development of experimental models of ocular pathologies (cell lines, in vitro and in vivo models).
  • Preclinical development of gene therapy for dry eye
  • Technology transfers: First clinical trial in ophthalmology using stem cells of non-ocular origin IOBA-NHC cell line (human conjunctival epithelium)
    • CERLab to Vision R&D
    • SIOBAL to AJL Ophthalmics S.A.
    • LIOCAN to AJL Ophthalmics S.A.
  • Method for detecting the risk of developing proliferative vitreoretinopathy
  • Pharmaceutical composition for the treatment and / or prevention of degenerative retinal diseases
  • Non-invasive intraocular pressure monitoring system
  • Nanoparticular system for the prevention and / or treatment of mucosal diseases
  • Reading visual rehabilitation program for patients with central field defect (IOBA-PEL)
  • Night driving simulator (IOBA HAXECST) Non-invasive sensor to determine functional characteristics of the cornea, device that includes this sensor and its use.


Other information

Number of researchers:

66

Technological Line(s):

- Health Sciences

Development status:

In research and development phase

Applicability of technology:

Yes

Companies and markets:

Research partners and clients Among the main partners and / or clients of the IOBA regarding research activities in vision sciences, the following stand out: Allergan Ferrer Advanced Biotherapeutics R&D Vision Thea Laboratories AJL Ophthalmics S.A. Novartis Abbvie Laboratories Patient associations: BEGISARE ACLARP ADE Retina Spain ICTIA (Aspaym Castilla y León) BLISTA (German Federation of the Blind and Visually Impaired) FAF (French Federation of the Visually Impaired) Dreaming Fingers (France)

Advantages:

Differentiating infrastructures:
The IOBA has differentiating infrastructures to carry out its research activities and which places at the service of its partners and / or clients:
  • Controlled Environmental Research Laboratory (CERLab): conducting studies and clinical trials under controlled environmental conditions
  • Ocular Pathology Laboratory (LPO): specialized in the study and diagnosis of eye samples
  • Clinical Trials Unit: design of protocols and advice in clinical trials in ophthalmology, design of data collection notebooks and accessory documentation of clinical trials, training in standards of good clinical practice
  • X-MAP technology in a Luminex-IS 100: Determination of tear molecules using multi-analyte analysis
  • Belmonte gas esthesiometer: determination of corneal sensitivity of mechanical, chemical and thermal type (hot and cold)
  • Night driving simulator (IOBA HAXECST)

Additional Information:

IOBA research groups:
  1. Ocular Surface (GSO): Collaborates closely with the IOBA corneal, immunology and ocular surface, uveitis and contact lens clinical units. This research group has 12 doctors as well as a variable number of predoctoral researchers, official master's students, four laboratory technicians and a research secretary.
  2. Retina: Research group aimed at solving problems not solved by current advances in retinal pathologies: identifying risk factors, studying the pathogenesis and proposing new therapeutic targets, among others, for different retinal diseases.
  3. Refractive surgery and quality of vision: Group dedicated to research in the fields of refractive surgery and anterior segment as well as rehabilitation to improve the vision and quality of life of patients.
  4. Glaucoma: The IOBA glaucoma unit started its activities in 1996 developing the diagnosis and surgical treatment of patients with glaucomatous optic neuropathy. Since then it has been characterized by its clinical and teaching excellence in this subspecialty, in addition to conducting clinical trials, evaluating new technologies and currently studying pharmacogenetics.
  5. Optometry: The development of research work in the field of optometry and vision sciences at the IOBA has been developing with a significant increase in its activity.
Ophthalmic Diagnostic Laboratories:
  1. Molecular Biology Laboratory (LBM): Diagnostic laboratory specialized in ophthalmology that has highly trained professionals for the handling and processing of all types of eye samples.
  2. Eye Pathology Laboratory (LPO): The Eye Pathology Anatomy Laboratory of the University Institute of Applied Ophthalmobiology (IOBA) of Valladolid is a laboratory specialized in the study and diagnosis of samples belonging to eyeballs.
Participation in scientific networks:

The IOBA, through its research groups and their main researchers, is part of the main biomedical research structures at national, regional and European level. As they are:
  • Network Biomedical Research Center: Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN); Carlos III Health Institute
  • Thematic Network for Cooperative Health Research (RETICS): Eye Pathologies (OftaRed); Carlos III Health Institute
  • Transversal Thematic Network of Cell Therapy (TerCel); Carlos III Health Institute
  • Networked Center for Regenerative Medicine and Cell Therapy of Castilla y León; Junta de Castilla y León and Instituto de Salud Carlos III
  • 3D-NET INTERNATIONAL CONSORTIUM
  • The European Network for Vision Impairment Training Education & Reserach (ENVITER).

UNESCO Code:

3201 - Clinical sciences

Other members:

Jose Carlos Pastor Jimeno
Iván Fernández Bueno

Photos

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Other resources

Related projects

Ocular Pathological Anatomy Laboratory (LPO)

The Ocular Pathological Anatomy Laboratory of Valladolid’s University Institute of Applied Ophthalmology (IOBA) is a laboratory specialized in the study and diagnosis of samples belonging to eyeballs, orbit and ocular appendages. Diagnostic servi... Read more >

Preclinical in vivo - IOBA

The University of Valladolid’s Institute of Applied Ophthalmo-Biology (IOBA), in collaboration with the Department of Medicine, Surgery and Veterinary Anatomy of the University of León, offers its services to companies or scientific groups for the... Read more >

Ophthalmology Reading Center (IOBA RC UVa)

The University of Valladolid’s IOBA reading center (IOBA-RC-UVA) offers the following services: - Consulting services: assistance in the development and preparation of clinical trial protocols. Assistance in the preparation of screening programs f... Read more >

Specialized training in vision sciences - IOBA

Doctorate in Vision Sciences. Training in research and university teaching aimed at graduates derived from degrees in Biology, Chemistry, Biochemistry, Biotechnology, Pharmacy, Physics, Medicine, Veterinary Medicine, Statistics, the former Compu... Read more >

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